Opportunity Information: Apply for W81XWH 21 ASADRP CA
The Department of Defense, through the U.S. Army Medical Research Acquisition Activity (USAMRAA), announced the Alcohol and Substance Abuse Disorders Research Program (ASADRP) Consortium Award (funding opportunity number W81XWH 21 ASADRP CA) to support a large, coordinated research consortium focused on alcohol and substance use disorders (ASUD). This opportunity is structured as a cooperative agreement, which typically means the government expects to have substantial involvement during the life of the project (for example, through coordination, milestone oversight, or programmatic input), rather than acting only as a passive funder.
The purpose of the Consortium Award is to drive multidisciplinary, team-based translational research that moves from discovery and preclinical work into studies in humans. The program is explicitly looking for efforts that (1) identify promising therapeutic compounds, (2) generate supporting preclinical evidence, and (3) conduct clinical research to evaluate potential medications or combinations of medications in people with ASUD who also have comorbid post-traumatic stress disorder (PTSD) and other psychological disorders. A key emphasis is on practical, treatment-oriented outcomes: testing interventions that could realistically become medications or medication strategies used in clinical settings, rather than limiting the work to basic science alone.
Another major theme is precision medicine. Applicants are expected to explore tools and approaches that help match individual patients to the most appropriate medication or medication combination. In practice, this could include investigating clinical characteristics, biomarkers, or other stratification methods that predict which patients will respond best to specific therapies, with the goal of improving outcomes and reducing trial-and-error prescribing in complex cases where ASUD overlaps with PTSD and related mental health conditions.
The overarching program goal is to reduce the overall burden of alcohol and substance use disorders across society, with an explicit interest in reducing opioid-related overdose deaths. While the program is housed within the Department of Defense, the announcement makes clear that the research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. That relevance requirement signals that proposals should clearly connect the scientific and clinical aims to real-world needs in military and veteran populations (and potentially broader civilian populations), particularly where trauma exposure, co-occurring mental health conditions, and substance use disorders intersect.
In terms of administrative details, this is a discretionary funding opportunity in the science and technology/research and development category (CFDA 12.420). Eligibility is listed as unrestricted, meaning any type of entity may apply as long as it meets any additional eligibility conditions described in the full program announcement. The posting indicated an expected number of one award, implying the intent to fund a single consortium effort rather than multiple independent smaller projects. The opportunity was originally posted June 16, 2021, with an original closing date of September 8, 2021. The award ceiling is listed as 0 in the source data, which commonly indicates that the specific maximum funding level was not captured in that field and would need to be confirmed in the full announcement text.
Overall, this opportunity is designed to fund a coordinated consortium that can span the full translational pipeline, bringing together expertise across disciplines to develop and test medication-based treatments for ASUD complicated by PTSD and other psychological comorbidities, while also advancing patient-matching approaches that could make those treatments more effective and more personalized.Apply for W81XWH 21 ASADRP CA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Alcohol and Substance Abuse Disorders Consortium Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jun 16, 2021.
- Applicants must submit their applications by Sep 08, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is the Alcohol and Substance Abuse Disorders Research Program (ASADRP) Consortium Award.
Who is offering this grant opportunity?
It is offered by the U.S. Department of Defense through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the funding opportunity number?
The funding opportunity number is W81XWH 21 ASADRP CA.
What type of award is this?
This opportunity is structured as a cooperative agreement.
What does a "cooperative agreement" mean for applicants and awardees?
A cooperative agreement typically means the government expects substantial involvement during the life of the project, such as coordination, milestone oversight, and/or programmatic input, rather than serving only as a passive funder.
What is the main purpose of the ASADRP Consortium Award?
The purpose is to support a large, coordinated research consortium focused on alcohol and substance use disorders (ASUD), with an emphasis on multidisciplinary, team-based translational research that moves from discovery and preclinical work into studies in humans.
Is this opportunity meant for a single project or multiple separate projects?
The posting indicated an expected number of one award, suggesting the intent to fund a single consortium effort rather than multiple independent smaller projects.
What research areas or activities is the program explicitly looking to support?
The program is explicitly looking for efforts that (1) identify promising therapeutic compounds, (2) generate supporting preclinical evidence, and (3) conduct clinical research to evaluate potential medications or combinations of medications in people with ASUD who also have comorbid PTSD and other psychological disorders.
Does the program focus on basic science, applied treatment development, or both?
The opportunity emphasizes practical, treatment-oriented outcomes, aiming to test interventions that could realistically become medications or medication strategies used in clinical settings, rather than limiting the work to basic science alone.
What populations should the proposed research focus on?
The clinical emphasis described includes people with alcohol and substance use disorders who also have comorbid post-traumatic stress disorder (PTSD) and other psychological disorders.
Is research on PTSD comorbidity required or just encouraged?
The program description specifically calls for clinical research evaluating potential medications or combinations in people with ASUD who also have comorbid PTSD and other psychological disorders, indicating that PTSD comorbidity is a central focus.
What is meant by "translational research" in this announcement?
In this opportunity, translational research refers to work that spans from discovery and preclinical evidence generation into clinical research in humans.
What is the role of precision medicine in this funding opportunity?
Precision medicine is a major theme. Applicants are expected to explore tools and approaches that help match individual patients to the most appropriate medication or medication combination.
What kinds of precision medicine tools or approaches are mentioned?
The announcement references investigating clinical characteristics, biomarkers, or other stratification methods that could predict which patients will respond best to specific therapies, with the goal of improving outcomes and reducing trial-and-error prescribing.
What is the overarching goal of the program?
The overarching goal is to reduce the overall burden of alcohol and substance use disorders across society, with an explicit interest in reducing opioid-related overdose deaths.
Is the program limited to opioid use disorder, or broader than that?
The program targets alcohol and substance use disorders broadly, while explicitly noting an interest in reducing opioid-related overdose deaths.
How must the research be relevant to military and veteran communities?
The announcement states that the research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. Proposals should clearly connect the scientific and clinical aims to real-world needs in military and veteran populations, especially where trauma exposure, co-occurring mental health conditions, and substance use disorders intersect.
Can projects address civilian populations as well?
Yes. The relevance requirement includes active-duty Service Members, Veterans, military beneficiaries, and/or the American public, which allows for broader public relevance alongside military and veteran relevance.
What is the CFDA number and program category?
The opportunity is listed under CFDA 12.420 and falls in the science and technology/research and development category.
Is this a discretionary grant opportunity?
Yes, it is described as a discretionary funding opportunity.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning any type of entity may apply as long as it meets any additional eligibility conditions described in the full program announcement.
Where should applicants look for any additional eligibility conditions?
Any additional eligibility conditions would be described in the full program announcement text.
When was this opportunity originally posted?
The opportunity was originally posted on June 16, 2021.
What was the original closing date?
The original closing date was September 8, 2021.
What is the maximum award amount (award ceiling)?
The award ceiling is listed as 0 in the source data, which commonly indicates the specific maximum funding level was not captured in that field and should be confirmed in the full announcement text.
Why might the award ceiling be shown as 0?
In the provided source data, an award ceiling of 0 commonly signals that the ceiling amount was not recorded in that specific field, not necessarily that funding is unavailable. The full announcement text is the appropriate place to confirm the actual maximum funding level.
What kind of project structure does the announcement envision?
The announcement envisions a large, coordinated consortium that can span the full translational pipeline and bring together expertise across disciplines to develop and test medication-based treatments for ASUD complicated by PTSD and other psychological comorbidities.
What is the main clinical outcome emphasis described?
The emphasis is on evaluating potential medications or combinations of medications in humans and advancing approaches that help match patients to the most appropriate medication strategy, aiming for realistic clinical application.
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