Opportunity Information: Apply for W81XWH 21 ASADRP CA
The Department of Defense, through the U.S. Army Medical Research Acquisition Activity (USAMRAA), announced the Alcohol and Substance Abuse Disorders Research Program (ASADRP) Consortium Award (funding opportunity number W81XWH 21 ASADRP CA) to support a large, coordinated research consortium focused on alcohol and substance use disorders (ASUD). This opportunity is structured as a cooperative agreement, which typically means the government expects to have substantial involvement during the life of the project (for example, through coordination, milestone oversight, or programmatic input), rather than acting only as a passive funder.
The purpose of the Consortium Award is to drive multidisciplinary, team-based translational research that moves from discovery and preclinical work into studies in humans. The program is explicitly looking for efforts that (1) identify promising therapeutic compounds, (2) generate supporting preclinical evidence, and (3) conduct clinical research to evaluate potential medications or combinations of medications in people with ASUD who also have comorbid post-traumatic stress disorder (PTSD) and other psychological disorders. A key emphasis is on practical, treatment-oriented outcomes: testing interventions that could realistically become medications or medication strategies used in clinical settings, rather than limiting the work to basic science alone.
Another major theme is precision medicine. Applicants are expected to explore tools and approaches that help match individual patients to the most appropriate medication or medication combination. In practice, this could include investigating clinical characteristics, biomarkers, or other stratification methods that predict which patients will respond best to specific therapies, with the goal of improving outcomes and reducing trial-and-error prescribing in complex cases where ASUD overlaps with PTSD and related mental health conditions.
The overarching program goal is to reduce the overall burden of alcohol and substance use disorders across society, with an explicit interest in reducing opioid-related overdose deaths. While the program is housed within the Department of Defense, the announcement makes clear that the research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. That relevance requirement signals that proposals should clearly connect the scientific and clinical aims to real-world needs in military and veteran populations (and potentially broader civilian populations), particularly where trauma exposure, co-occurring mental health conditions, and substance use disorders intersect.
In terms of administrative details, this is a discretionary funding opportunity in the science and technology/research and development category (CFDA 12.420). Eligibility is listed as unrestricted, meaning any type of entity may apply as long as it meets any additional eligibility conditions described in the full program announcement. The posting indicated an expected number of one award, implying the intent to fund a single consortium effort rather than multiple independent smaller projects. The opportunity was originally posted June 16, 2021, with an original closing date of September 8, 2021. The award ceiling is listed as 0 in the source data, which commonly indicates that the specific maximum funding level was not captured in that field and would need to be confirmed in the full announcement text.
Overall, this opportunity is designed to fund a coordinated consortium that can span the full translational pipeline, bringing together expertise across disciplines to develop and test medication-based treatments for ASUD complicated by PTSD and other psychological comorbidities, while also advancing patient-matching approaches that could make those treatments more effective and more personalized.Apply for W81XWH 21 ASADRP CA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Alcohol and Substance Abuse Disorders Consortium Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jun 16, 2021.
- Applicants must submit their applications by Sep 08, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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