Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) | RFA CA 25 006

Opportunity Information: Apply for RFA CA 25 006

This funding opportunity (RFA-CA-25-006) from the National Institutes of Health, specifically the National Cancer Institute (NCI), supports revision applications to active NCI-funded U01 projects. It is structured as a cooperative agreement (U01), meaning the funded work is expected to involve substantial scientific and/or programmatic involvement from NIH staff compared with a standard research grant. The central idea is straightforward: if a research team already has an ongoing NCI U01 project, they can request additional support to strengthen or speed up that parent project by adding in a novel technology that was developed with NCI Innovative Molecular Analysis Technologies (IMAT) program support. Clinical trials are optional under this NOFO, so projects may be either non-clinical or clinical in nature as long as they fit the revision scope.

The purpose of the revision is not to start a brand-new research direction unrelated to the parent award, but to expand the original research questions or accelerate progress toward the parent study goals by incorporating an IMAT-supported technical approach or device. In practice, that means proposing a well-justified integration of an emerging IMAT technology into the ongoing U01 research plan, with clear explanation of how the added technology enables stronger experimentation, faster or more informative data generation, better measurement capabilities, improved analytical performance, or otherwise increases the likelihood of timely scientific advances. A major emphasis is on independent validation, encouraging applicants to test and demonstrate that these new tools actually perform as expected in real research settings, and to help move the technologies closer to being broadly usable by the appropriate cancer research communities.

Programmatically, the NOFO sits within the NCI IMAT ecosystem and is designed to push interdisciplinary collaboration, especially collaborations that bridge technology development with real-world cancer research use cases. The expectation is that adding the IMAT-derived tool or method will not just be a peripheral add-on, but a meaningful enhancement that improves the rigor, reproducibility, suitability, or translational readiness of the ongoing study. This can include improved molecular analysis methods, devices, or other innovative measurement and analysis technologies that IMAT has supported, with the revision funds serving as an incentive to evaluate and deploy them in a way that demonstrates value and accelerates adoption.

From an administrative standpoint, the opportunity is categorized as discretionary funding and is associated with the Health and Education activity category. The CFDA number listed is 93.394. The application deadline is 2025-10-03. The award ceiling is $150,000, and NCI anticipates making about 3 awards under this announcement, indicating a relatively competitive, targeted effort focused on a small number of high-impact revisions.

Eligibility is broad and includes many types of domestic organizations, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); and small businesses. The NOFO also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities (foreign organizations), reflecting an intent to support diverse institutional participation where it aligns with the parent U01 award structure and goals.

Overall, this NOFO is best understood as a focused supplement-like pathway for existing NCI U01 teams to bring an IMAT-backed innovation into their ongoing cancer research, generate credible validation data, and deliver a faster or more definitive trajectory toward the scientific objectives of the parent project, with NCI actively involved through the cooperative agreement mechanism.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
• This funding opportunity was created on 2024-12-31.
• Applicants must submit their applications by 2025-10-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $150,000.00 in funding.
• The number of recipients for this funding is limited to 3 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 25 006

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