Opportunity Information: Apply for PA 18 607
Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) funding opportunity designed to push forward new methods and enabling technologies in natural products chemistry. The program is aimed at small business concerns that can bring genuinely innovative tools, platforms, or workflows that make it easier to discover, characterize, prioritize, and work with natural products and natural product-derived molecules. In practice, this means NIH is looking for technology development that can change what is feasible in the field, not just incremental improvements to existing approaches.
The funding mechanism is the SBIR R43/R44 series, which generally supports early-stage feasibility and prototype development (often associated with Phase I) and then further research, development, and potential commercialization steps (often associated with Phase II). The FOA is explicitly marked "Clinical Trial Not Allowed," which signals that the supported work must be preclinical and methods-focused rather than involving human subjects research that meets NIH’s definition of a clinical trial. Projects should stay centered on laboratory, analytical, computational, or engineering advances that strengthen natural products research capabilities.
The opportunity falls under the Health funding activity category (CFDA 93.213) and is offered as a discretionary grant. Eligible applicants are small businesses; foreign institutions and other non-U.S. entities are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible. However, the announcement notes that foreign components, as defined by the NIH Grants Policy Statement, may be allowed in some circumstances, meaning a U.S. small business might be able to include certain foreign elements (such as a specific collaboration or resource) if NIH rules permit and the application justifies it appropriately. Applicants would need to consult the FOA and NIH policy language to understand exactly what kinds of foreign involvement are permissible.
Key administrative details included in the listing are the funding opportunity number (PA-18-607), the original posting/creation date (January 30, 2018), and an original closing date of April 5, 2019. The public excerpt provided does not specify an award ceiling or the expected number of awards, so applicants would normally look to the full FOA text or NIH budgeting guidelines for typical SBIR limits and any institute-specific constraints. Overall, the focus is clear: support small businesses developing high-impact, innovative methods and technologies that materially advance the science and practical execution of natural products chemistry, while keeping the work outside the scope of clinical trials.Apply for PA 18 607
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2018-01-30.
- Applicants must submit their applications by 2019-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Frequently Asked Questions (FAQs)
What is the "Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed)" opportunity?
This is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) funding opportunity focused on developing new methods and enabling technologies in natural products chemistry. It supports innovations that make it easier to discover, characterize, prioritize, and work with natural products and natural product-derived molecules.
Which agency is offering this grant opportunity?
The opportunity is offered by the National Institutes of Health (NIH).
What is the funding mechanism for this opportunity?
The funding mechanism is SBIR R43/R44. This mechanism generally aligns with Phase I (feasibility and early development) and Phase II (further research and development and potential commercialization steps).
What is the funding opportunity number?
The funding opportunity number is PA-18-607.
What kinds of projects is NIH trying to fund through this FOA?
NIH is seeking genuinely innovative tools, platforms, or workflows that materially advance what is feasible in natural products chemistry. The emphasis is on methods and enabling technologies that strengthen natural products research capabilities, rather than incremental improvements to existing approaches.
What does "Methods Development" mean in the context of this opportunity?
Based on the listing, "methods development" refers to technology development centered on laboratory, analytical, computational, or engineering advances that improve how natural products are discovered, characterized, prioritized, and otherwise worked with in research and development settings.
Is this opportunity intended for clinical research involving human subjects?
No. The FOA is explicitly marked "Clinical Trial Not Allowed," meaning the supported work must be preclinical and methods-focused and must not involve human subjects research that meets NIH's definition of a clinical trial.
What does "Clinical Trial Not Allowed" require applicants to avoid?
Applicants must avoid proposing work that would be considered a clinical trial under NIH definitions. Projects should remain centered on preclinical methods development and enabling technologies rather than human-subjects clinical trial activities.
Who is eligible to apply?
Eligible applicants are small business concerns (small businesses).
Are foreign institutions or non-U.S. entities eligible to apply directly?
No. Foreign institutions and other non-U.S. entities are not eligible to apply.
Can a U.S. small business include a non-domestic component in its application?
No. Non-domestic components of U.S. organizations are not eligible.
Are any types of foreign involvement allowed at all?
Possibly. The listing notes that foreign components (as defined by the NIH Grants Policy Statement) may be allowed in some circumstances. This suggests a U.S. small business might be able to include specific foreign elements (such as a collaboration or resource) if NIH rules permit and the application justifies it appropriately. Applicants would need to consult the FOA and NIH policy language for the allowable scope.
What is the CFDA number and funding activity category?
The opportunity falls under the Health funding activity category with CFDA 93.213.
What type of grant is this described as?
It is described as a discretionary grant.
What are the key dates listed for this opportunity?
The listing includes an original posting/creation date of January 30, 2018, and an original closing date of April 5, 2019.
Does the excerpt state the maximum award amount (award ceiling)?
No. The public excerpt provided does not specify an award ceiling.
Does the excerpt state how many awards are expected?
No. The public excerpt provided does not specify the expected number of awards.
If award amounts and award counts are not specified in the excerpt, where would applicants typically look?
Applicants would normally look to the full FOA text and NIH budgeting guidance for typical SBIR limits and any institute-specific constraints.
What stage of development does the R43/R44 series generally support?
As summarized in the listing, the R43/R44 series generally supports early-stage feasibility and prototype development (often associated with Phase I) followed by further research and development and potential commercialization steps (often associated with Phase II).
What is the overall goal of this opportunity?
The overall goal is to support small businesses developing high-impact, innovative methods and technologies that materially advance natural products chemistry while keeping the work outside the scope of clinical trials.
What is meant by "high-impact" in this context?
Based on the description, "high-impact" implies methods or technologies that can change what is feasible in the field (enabling new capabilities or significantly improving effectiveness), rather than modest or incremental refinements of existing approaches.
What kinds of approaches are explicitly within scope according to the listing?
The listing indicates that laboratory, analytical, computational, and engineering advances that strengthen natural products research capabilities are within scope, as long as they remain methods-focused and do not involve clinical trials.
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