Opportunity Information: Apply for PA 18 607
Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) funding opportunity designed to push forward new methods and enabling technologies in natural products chemistry. The program is aimed at small business concerns that can bring genuinely innovative tools, platforms, or workflows that make it easier to discover, characterize, prioritize, and work with natural products and natural product-derived molecules. In practice, this means NIH is looking for technology development that can change what is feasible in the field, not just incremental improvements to existing approaches.
The funding mechanism is the SBIR R43/R44 series, which generally supports early-stage feasibility and prototype development (often associated with Phase I) and then further research, development, and potential commercialization steps (often associated with Phase II). The FOA is explicitly marked "Clinical Trial Not Allowed," which signals that the supported work must be preclinical and methods-focused rather than involving human subjects research that meets NIH’s definition of a clinical trial. Projects should stay centered on laboratory, analytical, computational, or engineering advances that strengthen natural products research capabilities.
The opportunity falls under the Health funding activity category (CFDA 93.213) and is offered as a discretionary grant. Eligible applicants are small businesses; foreign institutions and other non-U.S. entities are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible. However, the announcement notes that foreign components, as defined by the NIH Grants Policy Statement, may be allowed in some circumstances, meaning a U.S. small business might be able to include certain foreign elements (such as a specific collaboration or resource) if NIH rules permit and the application justifies it appropriately. Applicants would need to consult the FOA and NIH policy language to understand exactly what kinds of foreign involvement are permissible.
Key administrative details included in the listing are the funding opportunity number (PA-18-607), the original posting/creation date (January 30, 2018), and an original closing date of April 5, 2019. The public excerpt provided does not specify an award ceiling or the expected number of awards, so applicants would normally look to the full FOA text or NIH budgeting guidelines for typical SBIR limits and any institute-specific constraints. Overall, the focus is clear: support small businesses developing high-impact, innovative methods and technologies that materially advance the science and practical execution of natural products chemistry, while keeping the work outside the scope of clinical trials.Apply for PA 18 607
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2018-01-30.
- Applicants must submit their applications by 2019-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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