Opportunity Information: Apply for PA 17 089
The National Institutes of Health (NIH) funding opportunity titled "Exploratory Analyses of Existing Cohorts, Data Sets, and Stored Biospecimens to Address Clinical Aging Research Questions (R21)" (Funding Opportunity Number: PA-17-089; CFDA: 93.866) supports exploratory clinical aging research that relies on secondary analysis rather than new participant recruitment. The central purpose is to use existing longitudinal cohorts, previously collected datasets, and stored biospecimens housed in biorepositories to investigate how aging-related changes affect health across the lifespan, with a particular emphasis on clinically meaningful outcomes such as diseases, functional decline, and disabilities in older adults. The mechanism is an R21 grant, which is commonly used for early-stage, hypothesis-generating, and feasibility-oriented projects that can open the door to larger epidemiologic studies or future human intervention trials.
A key feature of this opportunity is its encouragement of innovative, clinically oriented hypotheses that can be tested by leveraging already available data resources. Projects are expected to focus on questions relevant to aging and health, including the development, progression, or consequences of age-associated conditions. Because the FOA is aimed at exploratory analyses, it is well-suited for studies that assess novel associations, develop preliminary risk or prognostic models, examine subgroup effects, or test whether certain biomarkers, clinical characteristics, or exposures measured earlier in life predict later-life outcomes. The announcement places special value on cohorts that can be linked to electronic health records (EHRs) and/or Centers for Medicare and Medicaid Services (CMS) administrative data, since these linkages can strengthen clinical outcome ascertainment, enable analyses of healthcare utilization, and provide richer longitudinal follow-up for aging populations.
The FOA also explicitly allows applicants to include certain supportive activities in their proposed budgets when those activities are necessary to accomplish the project aims. This includes costs for data harmonization (for example, aligning variables across multiple cohorts or standardizing measures collected under different protocols), archival activities (such as organizing and preparing datasets or biospecimen inventories for analysis), and assay refinement (improving, validating, or optimizing laboratory measurements on stored biospecimens when needed to test the study hypotheses). These activities are not meant to be stand-alone efforts; they need to be clearly tied to the specific scientific questions being addressed and should directly enable the proposed exploratory analyses.
In terms of award size, the listed award ceiling is $200,000, consistent with the modest, exploratory nature of the R21 mechanism. The source information lists an original closing date of 2020-05-07 (with a creation date of 2016-12-15), which signals that applicants should verify current submission dates and active cycles on NIH or Grants.gov if they intend to pursue the opportunity or any reissued/related announcements.
Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA further highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-U.S. (foreign) entities, and U.S. territories or possessions. This broad eligibility aligns with the FOA's emphasis on maximizing the use of existing research resources and encouraging participation from diverse institutions and communities.
Overall, this NIH R21 opportunity is designed for teams that already have access to well-characterized cohorts, curated datasets, and/or stored biospecimens and want to ask new clinical aging questions without the time and expense of building a new cohort from scratch. Competitive projects will typically present a clear and innovative clinical aging hypothesis, identify appropriate existing data and specimen resources to test it, justify any needed harmonization or assay work, and show how the exploratory findings will inform the next steps, such as a larger epidemiologic effort or a future clinical intervention study.Apply for PA 17 089
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Exploratory Analyses of Existing Cohorts, Data Sets, and Stored Biospecimens to Address Clinical Aging Research Questions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-12-15.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Exploratory Analyses of Existing Cohorts, Data Sets, and Stored Biospecimens to Address Clinical Aging Research Questions (R21)."
What is the funding opportunity number (FOA number)?
The Funding Opportunity Number listed is PA-17-089.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.866.
What type of grant mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism, which is commonly used for exploratory, early-stage, hypothesis-generating, and feasibility-oriented research.
What is the central purpose of this FOA?
The central purpose is to support exploratory clinical aging research by conducting secondary analyses of existing longitudinal cohorts, previously collected datasets, and/or stored biospecimens in biorepositories, rather than recruiting new participants.
Is new participant recruitment allowed or expected under this FOA?
The FOA is oriented toward secondary analysis and emphasizes relying on existing cohorts, datasets, and stored biospecimens rather than new participant recruitment.
What kinds of research questions are a good fit for this opportunity?
Projects should address clinical aging research questions about how aging-related changes affect health across the lifespan, with an emphasis on clinically meaningful outcomes. Examples described include studying diseases, functional decline, and disabilities in older adults, as well as the development, progression, or consequences of age-associated conditions.
What outcomes does the FOA emphasize as clinically meaningful?
The FOA highlights clinically meaningful outcomes such as diseases, functional decline, and disabilities in older adults.
What does "exploratory analyses" mean in the context of this FOA?
Within this FOA, exploratory analyses refer to hypothesis-generating and feasibility-focused work using existing resources to test innovative clinical aging hypotheses and produce results that can inform larger future studies.
What kinds of analyses are specifically mentioned as examples of appropriate exploratory work?
The FOA notes that appropriate projects can include assessing novel associations, developing preliminary risk or prognostic models, examining subgroup effects, and testing whether biomarkers, clinical characteristics, or exposures measured earlier in life predict later-life outcomes.
Does this opportunity encourage linking data to electronic health records (EHRs) or administrative claims data?
Yes. The FOA places special value on cohorts that can be linked to electronic health records (EHRs) and/or Centers for Medicare and Medicaid Services (CMS) administrative data.
Why are EHR and/or CMS linkages viewed as valuable for this FOA?
According to the FOA description, these linkages can strengthen clinical outcome ascertainment, enable analyses of healthcare utilization, and provide richer longitudinal follow-up for aging populations.
Can the proposed budget include data harmonization activities?
Yes. The FOA explicitly allows costs for data harmonization when necessary to accomplish the project aims, such as aligning variables across multiple cohorts or standardizing measures collected under different protocols.
Can the proposed budget include archival activities?
Yes. The FOA allows costs for archival activities (for example, organizing and preparing datasets or biospecimen inventories for analysis) when needed to accomplish the scientific aims.
Can the proposed budget include assay refinement work on stored biospecimens?
Yes. The FOA allows costs for assay refinement, such as improving, validating, or optimizing laboratory measurements on stored biospecimens, when needed to test the study hypotheses.
Are data harmonization, archival activities, or assay refinement allowed as stand-alone projects?
No. The FOA indicates these activities are not meant to be stand-alone efforts; they must be clearly tied to the specific scientific questions and should directly enable the proposed exploratory analyses.
What is the award ceiling for this R21 opportunity?
The listed award ceiling is $200,000.
How does the R21 mechanism align with the goals of this FOA?
The R21 mechanism is described as suitable for early-stage, hypothesis-generating, and feasibility-oriented projects, and the FOA is designed to generate exploratory findings that can open the door to larger epidemiologic studies or future human intervention trials.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic organizations. Examples listed include various levels of government entities; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are non-U.S. (foreign) entities eligible to apply?
Yes. The FOA explicitly includes non-U.S. (foreign) entities among eligible applicant categories.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA notes eligibility for U.S. territories or possessions.
Does the FOA encourage participation from specific institution types or community-based organizations?
Yes. The FOA highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, HBCUs, Hispanic-serving Institutions, TCCUs, as well as faith-based or community-based organizations, among others.
What kinds of research resources are expected for a strong application?
The FOA is designed for teams that already have access to well-characterized cohorts, curated datasets, and/or stored biospecimens and want to ask new clinical aging questions without creating a new cohort.
What characteristics are described as typical of a competitive project under this FOA?
Competitive projects are described as those that present a clear and innovative clinical aging hypothesis, identify appropriate existing data/specimen resources to test it, justify any needed harmonization or assay work, and explain how exploratory findings will inform next steps (such as a larger epidemiologic effort or a future clinical intervention study).
What is the listed closing date, and should applicants verify current due dates?
The source information lists an original closing date of 2020-05-07 (creation date 2016-12-15). The description notes that applicants should verify current submission dates and active cycles on NIH or Grants.gov for the most up-to-date status or any reissued/related announcements.
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