Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required) | RFA DA 25 019

Opportunity Information: Apply for RFA DA 25 019

Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-DA-25-019) designed to fund clinical trial research that tests enhanced, real-world models of care bringing HIV services, addiction treatment, and primary care into a more seamless and coordinated system. The central goal is to support studies that evaluate whether these integrated approaches improve outcomes for people affected by HIV and substance use disorders, especially in settings where fragmented care, missed appointments, stigma, and unmet medical and behavioral health needs can undermine treatment engagement and long-term health.

This opportunity uses the NIH R01 mechanism and explicitly requires a clinical trial, meaning applicants should be prepared to propose a rigorous, prospective evaluation of an intervention or service-delivery model. In practical terms, the funded work is expected to go beyond describing a program and instead test an integrated care model in a way that generates strong evidence about effectiveness, implementation, and potential for scale. While the public summary is brief, the emphasis on "enhanced models" and "optimally integrate" signals a focus on testing improvements over usual care, such as stronger coordination between HIV and addiction care teams, better linkage and retention strategies, streamlined screening and treatment workflows, and integrated primary care that addresses co-occurring conditions and preventive health needs alongside HIV and substance use treatment.

The activity category is listed under education and health, and the CFDA number associated with the opportunity is 93.279. The eligible applicant pool is broad, reflecting an intent to encourage participation from many types of organizations that serve populations impacted by HIV and addiction. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. NIH also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; Indian/Native American tribal governments that are not federally recognized; and non-U.S. entities (foreign organizations), indicating an openness to a wide range of institutional and community partners.

Key administrative details in the source information include an original closing date of March 19, 2025, and a creation date of July 19, 2023. The award ceiling and expected number of awards are not specified in the provided listing, so prospective applicants would need to consult the full FOA text for budget limits, project period expectations, review criteria, and any required components such as study design features, target populations, allowable sites, data and safety monitoring expectations, and any NIH-specific policies tied to clinical trial conduct.

Overall, this FOA is aimed at accelerating evidence-based, integrated service delivery that can help reduce HIV transmission and improve health outcomes by meeting people where they are with coordinated HIV care, substance use treatment, and primary care in a single, better-connected model, and by testing those models through a clinical trial approach that can inform broader adoption.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2023-07-19.
• Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 25 019

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